Anti-ACE Antibody Picoband® Fluoro488 Conjugated

This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms.

E.coli-derived human ACE recombinant protein (Position: R149-C545) . Human ACE shares 90.4% and 91.4% amino acid (aa) sequence identity with mouse and rat ACE, respectively.

1. Alfalah, M., Parkin, E. T., Jacob, R., Sturrock, E. D., Mentele, R., Turner, A. J., Hooper, N. M., Naim, H. Y. A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase. J. Biol. Chem. 276: 21105-21109, 2001. 2. Amant, C., Bauters, C., Bodart, J.-C., Lablanche, J.-M., Grollier, G., Danchin, N., Hamon, M., Richard, F., Helbecque, N., McFadden, E. P., Amouyel, P., Bertrand, M. E. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation 96: 56-60, 1997. 3. Arbustini, E., Grasso, M., Fasani, R., Klersy, C., Diegoli, M., Porcu, E., Banchieri, N., Fortina, P., Danesino, C., Specchia, G. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Brit. Heart J. 74: 584-591, 1995.