Anti-EDNRB Antibody Picoband® Fluoro488 Conjugated

Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

E.coli-derived human EDNRB recombinant protein (Position: E27-Y439) . Human EDNRB shares 89.9% amino acid (aa) sequence identity with both mouse and rat EDNRB.

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