Anti-PKN3 Antibody Picoband® Fluoro550 Conjugated

Protein kinase N3 is a serine/threonine protein kinase and one of three PKN isoforms (PKN1, PKN2, PKN3) encoded by independent genes. PKN3 has been identified as an effector that mediates malignant prostate cell growth and is activated by PI3-kinase.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/23/2007. 2. Leenders, F., Mopert, K., Schmiedeknecht, A., Santel, A., Czauderna, F., Aleku, M., Penschuck, S., Dames, S., Sternberger, M., Rohl, T., Wellmann, A., Arnold, W., Giese, K., Kaufmann, J., Klippel, A. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. EMBO J. 23: 3303-3313, 2004. 3. Oishi, K., Mukai, H., Shibata, H., Takahashi, M., Ona, Y. Identification and characterization of PKN-beta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKN-alpha. Biochem. Biophys. Res. Commun. 261: 808-814, 1999.