Anti-PKN3 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Protein kinase N3 is a serine/threonine protein kinase and one of three PKN isoforms (PKN1, PKN2, PKN3) encoded by independent genes. PKN3 has been identified as an effector that mediates malignant prostate cell growth and is activated by PI3-kinase.
Gene Name
PKN3
Gene ID
29941
UniProt
Q6P5Z2
Host
Rabbit
Reactivity
Human
Immunogen
E.coli-derived human PKN3 recombinant protein (Position: E2-P889) . Human PKN3 shares 83.7% amino acid (aa) sequence identity with mouse PKN3.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/23/2007. 2. Leenders, F., Mopert, K., Schmiedeknecht, A., Santel, A., Czauderna, F., Aleku, M., Penschuck, S., Dames, S., Sternberger, M., Rohl, T., Wellmann, A., Arnold, W., Giese, K., Kaufmann, J., Klippel, A. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. EMBO J. 23: 3303-3313, 2004. 3. Oishi, K., Mukai, H., Shibata, H., Takahashi, M., Ona, Y. Identification and characterization of PKN-beta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKN-alpha. Biochem. Biophys. Res. Commun. 261: 808-814, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
99 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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