Anti-PHYHIPL Antibody Picoband® Fluoro550 Conjugated

Phytanoyl-CoA hydroxylase-interacting protein-like is an enzyme that in humans is encoded by the PHYHIPL gene. PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein-like), also known as phytanoyl-CoA hydroxylase-interacting protein-like, is a 376 amino acid protein that contains one fibronectin type-III domain and belongs to the PHYHIP family. Conserved in chimpanzee, canine, mouse, rat, chicken, zebrafish and Caenorhabditis elegans, PHYHIPL exists as three alternatively spliced isoforms. PHYHIPL is a down-regulated target of IRX1, a homeobox tumor suppressor gene linked to gastric carcinoma. PHYHIPL may also play a role in the development of the central system. The gene that encodes PHYHIPL maps to human chromosome 10q21.1.

E.coli-derived human PHYHIPL recombinant protein (Position: M1-D336) . Human PHYHIPL shares 97.3% and 96.7% amino acid (aa) sequence identity with mouse and rat PHYHIPL, respectively.

1. Fu, H., Ge, B., Chen, D., Wu, Y., Luo, Q., Li, X., ... & Tang, Q. (2019) . Phytanoyl-CoA 2-hydroxylase-interacting protein-like gene is a therapeutic target gene for glioblastoma multiforme. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 25, 2583. 2. Sugimoto, H., Horii, T., Hirota, J. N., Sano, Y., Shinoda, Y., Konno, A., ... & Sadakata, T. (2021) . The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Molecular Brain, 14, 1-9. 3. Ying, H., Zheng, H., Scott, K., Wiedemeyer, R., Yan, H., Lim, C., ... & DePinho, R. A. (2010) . Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences, 107 (15), 6912-6917.