Anti-RRN3 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1.
Gene Name
RRN3
Gene ID
54700
UniProt
Q9NYV6
Host
Rabbit
Reactivity
Human
Immunogen
E.coli-derived human RRN3 recombinant protein (Position: D184-L651) . Human RRN3 shares 87.4% amino acid (aa) sequence identity with mouse RRN3.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Mayer, C., Bierhoff, H., Grummt, I. The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev. 19: 933-941, 2005. 2. Moorefield, B., Greene, E. A., Reeder, R. H. RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human. Proc. Nat. Acad. Sci. 97: 4724-4729, 2000. 3. Yuan, X., Zhou, Y., Casanova, E., Chai, M., Kiss, E., Grone, H.-J., Schutz, G., Grummt, I. Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Molec. Cell 19: 77-87, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
74 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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