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Anti-RERE Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene. This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name

RERE

Gene ID

473

UniProt

Q9P2R6

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human RERE recombinant protein (Position: D109-H1037) . Human RERE shares 92.4% and 92.3% amino acid (aa) sequence identity with mouse and rat RERE, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Amler, L. C., Bauer, A., Corvi, R., Dihlmann, S., Praml, C., Cavenee, W. K., Schwab, M., Hampton, G. M. Identification and characterization of novel genes located at the t (1;15) (p36.2; q24) translocation breakpoint in the neuroblastoma cell line NGP. Genomics 64: 195-202, 2000. 2. Bosch, D. G. M., Boonstra, F. N., de Leeuw, N., Pfundt, R., Nillesen, W. M., de Ligt, J., Gilissen, C., Jhangiani, S., Lupski, J. R., Cremers, F. P. M., de Vries, B. B. A. Novel genetic causes for cerebral visual impairment. Europ. J. Hum. Genet. 24: 660-665, 2016. 3. Fregeau, B., Kim, B. J., Hernandez-Garcia, A., Jordan, V. K., Cho, M. T., Schnur, R. E., Monaghan, K. G., Juusola, J., Rosenfeld, J. A., Bhoj, E., Zackai, E. H., Sacharow, S., and 14 others. De novo mutations of RERE cause a genetic syndrome with features that overlap those associated with proximal 1p36 deletions. Am. J. Hum. Genet. 98: 963-970, 2016.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

172,109 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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