Anti-CREB1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
Gene Name
CREB1
Gene ID
1385
UniProt
P16220
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Immunogen
E.coli-derived human CREB1 recombinant protein (Position: A7-R270) . Human CREB1 shares 99.6% and 99.2% amino acid (aa) sequence identity with mouse and rat CREB1, respectively.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Antonescu, C. R., Dal Cin, P., Nafa, K., Teot, L. A., Surti, U., Fletcher, C. D., Ladanyi, M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 46: 1051-1060, 2007. 2. Barco, A., Alarcon, J. M., Kandel, E. R. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108: 689-703, 2002. 3. Barton, C. H., Ajioka, J. W., Roach, T. I. A., Blackwell, J. M. Mapping Creb-1 to chromosome 1 in the mouse. Genomics 14: 790-792, 1992.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
36,37,25 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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