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Anti-PLS1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.

Gene Name

PLS1

Gene ID

5357

UniProt

Q14651

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human PLS1 recombinant protein (Position: E14-L581) . Human PLS1 shares 93.8% amino acid (aa) sequence identity with mouse PLS1.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Diaz-Horta, O., Bademci, G., Tokgoz-Yilmaz, S., Guo, S., Zafeer, F., Sineni, C. J., Duman, D., Farooq, A., Tekin, M. Novel variant pE269K confirms causative role of PLA1 mutations in autosomal dominant hearing loss. Clin. Genet. 96: 575-578, 2019. 2. Grimm-Gunter, E-M. S., Revenu, C., Ramos, S., Hurbain, I., Smyth, N., Ferrary, E., Louvard, D., Robine, S., Rivero, F. Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Molec. Biol. Cell 20: 2549-2562, 2009. 3. Lin, C.-S., Shen, W., Chen, Z. P., Tu, Y.-H., Matsudaira, P. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Molec. Cell. Biol. 14: 2457-2467, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

70 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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