Anti-RTF2 Antibody Picoband®

Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene. Replication Termination Factor 2, often abbreviated as RTF2, is a protein involved in the regulation and termination of DNA replication processes in eukaryotic cells. It plays a crucial role in ensuring the accurate completion of DNA synthesis during cell division by coordinating the termination of replication forks at specific sites along the DNA strands. RTF2 functions by interacting with other proteins and DNA sequences to facilitate the orderly disassembly of the replication machinery and the prevention of unnecessary re-replication of genomic regions. Its activity is tightly regulated to maintain genomic stability and fidelity, making it a key player in cell cycle control mechanisms. Studies on RTF2 have provided insights into the molecular mechanisms governing DNA replication termination and its implications for cellular function and genome maintenance.

E.coli-derived human RTF2 recombinant protein (Position: D4-F306) . Human RTF2 shares 87.8% and 88.1% amino acid (aa) sequence identity with mouse and rat RTF2, respectively.

1. Chia, B. S., Li, B., Cui, A., Eisenhaure, T., Raychowdhury, R., Lieb, D., & Hacohen, N. (2020) . Loss of the nuclear protein RTF2 enhances influenza virus replication. Journal of Virology, 94 (22), 10-1128. 2. Suo, D., Wang, L., Zeng, T., Zhang, H., Li, L., Liu, J., ... & Li, Y. (2020) . NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2. Oncogenesis, 9 (8), 75. 3. Kottemann, M. C., Conti, B. A., Lach, F. P., & Smogorzewska, A. (2018) . Removal of RTF2 from stalled replisomes promotes maintenance of genome integrity. Molecular cell, 69 (1), 24-35.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.