Anti-EGR2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS) . Multiple transcript variants encoding two different isoforms have been found for this gene.
Gene Name
EGR2
Gene ID
1959
UniProt
P11161
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human EGR2 recombinant protein (Position: M1-R257) . Human EGR2 shares 90.7% amino acid (aa) sequence identity with both mouse and rat EGR2.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Boerkoel, C. F., Takashima, H., Bacino, C. A., Daentl, D., Lupski, J. R. EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Neurogenetics 3: 153-157, 2001. 2. Chavrier, P., Janssen-Timmen, U., Mattei, M.-G., Zerial, M., Bravo, R., Charnay, P. Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos. Molec. Cell. Biol. 9: 787-797, 1989. 3. Chung, K. W., Sunwoo, I. N., Kim, S. M., Park, K. D., Kim, W.-K., Kim, T. S., Koo, H., Cho, M., Lee, J., Choi, B. O. Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family. Neurogenetics 6: 159-163, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50,45 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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