Anti-PDLIM4 Antibody Picoband® Fluoro647 Conjugated

PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene. RIL, also known as PDLIM4 is a putative tumor suppressor gene. RIL is transcriptionally repressed by hypermethylation in a variety of tumors including breast and prostate. The difference in methylation status of RIL between normal and cancerous tissues is being investigated as to determine the use of RIL as a potential biomarker. Two isoforms of human RIL one have been identified.

E.coli-derived human PDLIM4 recombinant protein (Position: Y137-D271) . Human PDLIM4 shares 91.2% and 89% amino acid (aa) sequence identity with mouse and rat PDLIM4, respectively.

1. Bashirova, A. A., Markelov, M. L., Shlykova, T. V., Levshenkova, E. V., Alibaeva, R. A., Frolova, E. I. The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts. Gene 210: 239-245, 1998. 2. Boumber, Y. A., Kondo, Y., Chen, X., Shen, L., Gharibyan, V., Konishi, K., Estey, E., Kantarjian, H., Garcia-Manero, G., Issa, J.-P. J. RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis. Cancer Res. 67: 1997-2005, 2007. 3. Kiess, M., Scharm, B., Aguzzi, A., Hajnal, A., Klemenz, R., Schwarte-Waldhoff, I., Schafer, R. Expression of ril, a novel LIM domain gene, is down-regulated in Hras-transformed cells and restored in phenotypic revertants. Oncogene 10: 61-68, 1995.