Anti-P3H2 Antibody Picoband® Fluoro488 Conjugated

This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

E.coli-derived human P3H2 recombinant protein (Position: E106-R494) . Human P3H2 shares 88.9% and 89.5% amino acid (aa) sequence identity with mouse and rat P3H2, respectively.

1. Gross, M. B. Personal Communication. Baltimore, Md. 10/18/2011. 2. Guo, H., Tong, P., Peng, Y., Wang, T., Liu, Y., Chen, J., Li, Y., Tian, Q., Hu, Y., Zheng, Y., Xiao, L., Xiong, W., Pan, Q., Hu, Z., Xia, K. Homozygous loss-of-function mutation of the LEPREL1 gene causes severe non-syndromic high myopia with early-onset cataract. Clin. Genet. 86: 575-579, 2014. 3. Jarnum, S., Kjellman, C., Darabi, A., Nilsson, I., Edvardsen, K., Aman, P. LEPREL1, a novel ER and Golgi resident member of the Leprecan family. Biochem. Biophys. Res. Commun. 317: 342-351, 2004.