Anti-ENO1 Antibody Picoband® Fluoro647 Conjugated

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.

1. Comings, D. E. Evidence for ancient tetraploidy and conservation of linkage groups in mammalian chromosomes. Nature 238: 455-457, 1972. 2. D'Ancona, G. G., Chern, C. J., Benn, P., Croce, C. M. Assignment of the human gene for enolase 1 to region pter-p36 of chromosome 1. Cytogenet. Cell Genet. 18: 327-332, 1977. 3. D'Ancona, G. G., Croce, C. M. Assignment of the gene for enolase to mouse chromosome 4 using somatic cell hybrids. Cytogenet. Cell Genet. 19: 1-6, 1977.