Anti-SYNPO2L Antibody Picoband®

SYNPO2L belongs to the synaptopodin family and is an actin-associated protein that may play a role in modulating actin-based shape. SYNPO2L is involved in the positive regulation of Rho protein signal transduction and the positive regulation of stress fiber assembly. Loss-of-function variants in the SYNPO2L gene are associated with atrial fibrillation

E.coli-derived human SYNPO2L recombinant protein (Position: H66-E923) . Human SYNPO2L shares 87.9% amino acid (aa) sequence identity with mouse SYNPO2L.

1. Lubitz, S. A., Brody, J. A., Bihlmeyer, N. A., Roselli, C., Weng, L. C., Christophersen, I. E., ... & Lin, H. (2016) . Whole exome sequencing in atrial fibrillation. PLoS genetics, 12 (9), e1006284. 2. Van Eldik, W., Den Adel, B., Monshouwer-Kloots, J., Salvatori, D., Maas, S., Van Der Made, I., ... & Beqqali, A. (2017) . Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart. PLoS One, 12 (12), e0189139. 3. Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., ... & Kääb, S. (2012) . Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature genetics, 44 (6), 670-675.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.