Anti-NOXA1 Antibody Picoband®

NADPH oxidase activator 1 is an enzyme that in humans is encoded by the NOXA1 gene. This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human NOXA1 recombinant protein (Position: A38-Q434) . Human NOXA1 shares 60.3% and 61% amino acid (aa) sequence identity with mouse and rat NOXA1, respectively.

1. Ambasta, R. K., Schreiber, J. G., Janiszewski, M., Busse, R., Brandes, R. P. Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Free Radic. Biol. Med. 41: 193-201, 2006. 2. Banfi, B., Clark, R. A., Steger, K., Krause, K.-H. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J. Biol. Chem. 278: 3510-3513, 2003. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 7/25/2007.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.