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Anti-ANKRD1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Ankyrin repeat domain-containing protein 1, or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene also known as CARP. The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.

Gene Name

ANKRD1

Gene ID

27063

UniProt

Q15327

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human ANKRD1 recombinant protein (Position: D120-F319) . Human ANKRD1 shares 93.5% and 95% amino acid (aa) sequence identity with mouse and rat ANKRD1, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Chu, W., Burns, D. K., Swerlick, R. A., Presky, D. H. Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells. J. Biol. Chem. 270: 10236-10245, 1995. 2. de Waard, V., van Achterberg, T. A. E., Beauchamp, N. J., Pannekoek, H., de Vries, C. J. M. Cardiac ankyrin repeat protein (CARP) expression in human and murine atherosclerotic lesions: activin induces Carp in smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23: 64-68, 2003. 3. Kanai, H., Tanaka, T., Aihara, Y., Takeda, S., Kawabata, M., Miyazono, K., Nagai, R., Kurabayashi, M. Transforming growth factor-beta/Smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells. Circ. Res. 88: 30-36, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

36 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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