Anti-ANKRD1 Antibody Picoband®

Ankyrin repeat domain-containing protein 1, or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene also known as CARP. The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.

E.coli-derived human ANKRD1 recombinant protein (Position: D120-F319) . Human ANKRD1 shares 93.5% and 95% amino acid (aa) sequence identity with mouse and rat ANKRD1, respectively.

1. Chu, W., Burns, D. K., Swerlick, R. A., Presky, D. H. Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells. J. Biol. Chem. 270: 10236-10245, 1995. 2. de Waard, V., van Achterberg, T. A. E., Beauchamp, N. J., Pannekoek, H., de Vries, C. J. M. Cardiac ankyrin repeat protein (CARP) expression in human and murine atherosclerotic lesions: activin induces Carp in smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23: 64-68, 2003. 3. Kanai, H., Tanaka, T., Aihara, Y., Takeda, S., Kawabata, M., Miyazono, K., Nagai, R., Kurabayashi, M. Transforming growth factor-beta/Smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells. Circ. Res. 88: 30-36, 2001.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.