Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-RTKN2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Rhotekin 2 is a protein in humans that is encoded by the RTKN2 gene. The RTKN2 gene encodes a protein known as Rhotekin-2, which is involved in various cellular processes, including cytoskeletal organization, cell migration, and signal transduction. RTKN2 interacts with Rho GTPases, particularly RhoA, and modulates their activity to regulate actin cytoskeleton dynamics and cell morphology. This protein plays a role in cell adhesion and migration, with implications for tissue development, wound healing, and cancer metastasis. Additionally, RTKN2 has been linked to synaptic plasticity and neuronal development in the brain. Dysregulation of RTKN2 expression or function has been associated with neurological disorders, cardiovascular diseases, and cancer progression. Elucidating the molecular mechanisms underlying RTKN2's diverse functions is crucial for understanding its physiological roles and its potential as a therapeutic target for various diseases.

Gene Name

RTKN2

Gene ID

219790

UniProt

Q8IZC4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human RTKN2 recombinant protein (Position: M1-D572) . Human RTKN2 shares 71.8% amino acid (aa) sequence identity with mouse RTKN2.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Collier, F. M., Gregorio-King, C. C., Gough, T. J., Talbot, C. D., Walder, K., Kirkland, M. A. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. Biochem. Biophys. Res. Commun. 324: 1360-1369, 2004. 2. Collier, F. M., Loving, A., Baker, A. J., McLeod, J., Walder, K., Kirkland, M. A. RTKN2 induces NF-kappaB dependent resistance to intrinsic apoptosis in HEK cells and regulates BCL-2 genes in human CD4+ lymphocytes. J. Cell Death 2: 9-23, 2009. Note: Electronic Article. 3. Gregorio-King, C. C., Gough, T., Van Der Meer, G. J., Hosking, J. B., Waugh, C. M., McLeod, J. L., Collier, F. M., Kirkland, M. A. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. J. Steroid Biochem. Molec. Biol. 88: 311-320, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

69 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

CASP7 Knockout A-549 Cell Line
ARG0074 1 Million

CASP7 Knockout A-549 Cell Line

Ask
View Details
pCMV-SPORT6-Cnpy2 Plasmid
PVT53413 2 µg

pCMV-SPORT6-Cnpy2 Plasmid

Ask
View Details
Glucokinase (GCK) Rabbit pAb
E96293 100 µL

Glucokinase (GCK) Rabbit pAb

Ask
View Details
WBP1 siRNA Oligos set (Human)
50272171 3x 5 nmol

WBP1 siRNA Oligos set (Human)

Ask
View Details