Anti-FAM40B/STRIP2 Antibody Picoband®

The STRIP2 gene encodes a protein known as striatin-interacting protein 2, which interacts with striatin, a scaffolding protein involved in diverse cellular processes such as signaling, cell adhesion, and transcriptional regulation. STRIP2 is implicated in cardiac development and function, where it modulates cardiac hypertrophy, contractility, and arrhythmogenesis. Additionally, it plays roles in neuronal development and synaptic plasticity in the brain. Dysregulation of STRIP2 expression or function has been associated with various cardiovascular disorders, including hypertrophic cardiomyopathy and arrhythmias, as well as neurodevelopmental disorders such as autism spectrum disorders. Elucidating the molecular mechanisms underlying STRIP2 function is essential for understanding its physiological roles in cardiac and neural tissues and its potential implications for disease pathology and therapeutic targeting.

E.coli-derived human FAM40B/STRIP2 recombinant protein (Position: H173-Q507) . Human STRIP2 shares 96.4% amino acid (aa) sequence identity with mouse STRIP2.

1. Gross, M. B. Personal Communication. Baltimore, Md. 3/22/2018. 2. Kemp, H. A., Sprague, G. F., Jr. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Molec. Cell. Biol. 23: 1750-1763, 2003. 3. Madsen, C. D., Hooper, S., Tozluoglu, M., Bruckbauer, A., Fletcher, G., Erler, J. T., Bates, P. A., Thompson, B., Sahai, E. STRIPAK components determine mode of cancer cell migration and metastasis. Nature Cell Biol. 17: 68-80, 2015.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.