Anti-Annexin A2/ANXA2 Antibody Picoband®

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms.

A synthetic peptide corresponding to a sequence at the N-terminus of human ANXA2, which shares 92.9% and 100% amino acid (aa) sequence identity with mouse and rat ANXA2, respectively.

1. Huang, K.-S., Wallner, B. P., Mattaliano, R. J., Tizard, R., Burne, C., Frey, A., Hession, C., McGray, P., Sinclair, L. K., Chow, E. P., Browning, J. L., Ramachandran, K. L., Tang, J., Smart, J. E., Pepinsky, R. B. Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60 (v-src) and of the epidermal growth factor receptor/kinase. Cell 46: 191-199, 1986. 2. Huebner, K., Cannizzaro, L. A., Croce, C. M., Frey, A. Z., Wallner, B. P., Hecht, B. K., Hecht, F. Chromosome localization of the human genes for lipocortin I and the lipocortin II family. (Abstract) Cytogenet. Cell Genet. 46: 631 only, 1987. 3. Huebner, K., Cannizzaro, L. A., Frey, A. Z., Hecht, B. K., Hecht, F., Croce, C. M., Wallner, B. P. Chromosomal localization of the human genes for lipocortin I and lipocortin II. Oncogene Res. 2: 299-310, 1988.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.