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Anti-GLMN Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Glomulin is a protein that in humans is encoded by the GLMN gene. This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene.

Gene Name

GLMN

Gene ID

11146

UniProt

Q92990

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human GLMN recombinant protein (Position: Q153-R574) . Human GLMN shares 85.4% amino acid (aa) sequence identity with mouse GLMN.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Arai, T., Kasper, J. S., Skaar, J. R., Ali, S. H., Takahashi, C., DeCaprio, J. A. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc. Nat. Acad. Sci. 100: 9855-9860, 2003. 2. Brouillard, P., Boon, L. M., Mulliken, J. B., Enjolras, O., Ghassibe, M., Warman, M. L., Tan, O. T., Olsen, B. R., Vikkula, M. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ('glomangiomas') . Am. J. Hum. Genet. 70: 866-874, 2002. 3. Brouillard, P., Olsen, B. R., Vikkula, M. High-resolution physical and transcript map of the locus for venous malformations with glomus cells (VMGLOM) on chromosome 1p21-p22. Genomics 67: 96-101, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

68 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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