Anti-GLMN Antibody Picoband®

Glomulin is a protein that in humans is encoded by the GLMN gene. This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene.

1. Arai, T., Kasper, J. S., Skaar, J. R., Ali, S. H., Takahashi, C., DeCaprio, J. A. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc. Nat. Acad. Sci. 100: 9855-9860, 2003. 2. Brouillard, P., Boon, L. M., Mulliken, J. B., Enjolras, O., Ghassibe, M., Warman, M. L., Tan, O. T., Olsen, B. R., Vikkula, M. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ('glomangiomas') . Am. J. Hum. Genet. 70: 866-874, 2002. 3. Brouillard, P., Olsen, B. R., Vikkula, M. High-resolution physical and transcript map of the locus for venous malformations with glomus cells (VMGLOM) on chromosome 1p21-p22. Genomics 67: 96-101, 2000.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.