Anti-GLG1 Antibody Picoband®

Golgi apparatus protein 1 is a protein that in humans is encoded by the GLG1 gene. The GLG1 gene, also known as Golgi apparatus protein 1, encodes a protein involved in maintaining the structural integrity and function of the Golgi apparatus, a vital organelle involved in protein processing and trafficking within the cell. GLG1 is associated with the formation of Golgi stacks and the regulation of vesicular transport between the endoplasmic reticulum and Golgi complex. It plays a critical role in protein glycosylation, sorting, and secretion. Dysregulation of GLG1 expression or function has been implicated in various cellular processes and diseases, including cancer progression, neurodegenerative disorders, and congenital disorders of glycosylation. Understanding the molecular mechanisms underlying GLG1 function is essential for unraveling its role in cellular physiology and its potential as a therapeutic target for diseases associated with Golgi dysfunction.

E.coli-derived human GLG1 recombinant protein (Position: E173-K1040) . Human GLG1 shares 98.5% and 98% amino acid (aa) sequence identity with mouse and rat GLG1, respectively.

1. Gonatas, J. O., Mezitis, S. G. E., Stieber, A., Fleischer, B., Gonatas, N. K. MG-160. A novel sialoglycoprotein of the medical cisternae of the Golgi apparatus. J. Biol. Chem. 264: 646-653, 1989. 2. Mourelatos, Z., Gonatas, J. O., Cinato, E., Gonatas, N. K. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. DNA Cell Biol. 15: 1121-1128, 1996. 3. Mourelatos, Z., Gonatas, J. O., Nycum, L. M., Gonatas, N. K., Biegel, J. A. Assignment of the GLG1 gene for MG-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. Genomics 28: 354-355, 1995.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.