Anti-ITPKC Antibody Picoband® Fluoro488 Conjugated

This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins (1,4,5) P (3) ] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.

E.coli-derived human ITPKC recombinant protein (Position: D292-E607) . Human ITPKC shares 88.1% and 88% amino acid (aa) sequence identity with mouse and rat ITPKC, respectively.

1. Chi, H., Huang, F.-Y., Chen, M.-R., Chiu, N.-C., Lee, H.-C., Lin, S.-P., Chen, W.-F., Lin, C.-L., Chan, H.-W., Liu, H.-F., Huang, L.-M., Lee, Y.-J. ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children. Hum. Molec. Genet. 19: 1147-1151, 2010. 2. Dewaste, V., Pouillon, V., Moreau, C., Shears, S., Takazawa, K., Erneux, C. Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C. Biochem. J. 352: 343-351, 2000. 3. Hamosh, A. Personal Communication. Baltimore, Md. 5/6/2020.