Anti-VGLUT2/SLC17A6 Antibody Picoband® Fluoro594 Conjugated

Solute carrier family 17 (vesicular glutamate transporter), member 6 is a protein that in humans is encoded by the SLC17A6 gene. The SLC17A6 gene, also known as vesicular glutamate transporter 2 (VGLUT2), encodes a protein responsible for transporting the neurotransmitter glutamate into synaptic vesicles in neurons. This process is crucial for glutamatergic neurotransmission, which plays a fundamental role in synaptic communication and neuronal excitability. SLC17A6/VGLUT2 is primarily expressed in excitatory neurons in various regions of the brain, including the cerebral cortex, hippocampus, and thalamus. Dysregulation of SLC17A6 expression or function has been implicated in neurological disorders such as epilepsy, schizophrenia, and Parkinson's disease, highlighting its significance in brain function and disease pathology. Understanding the molecular mechanisms underlying SLC17A6/VGLUT2 function is essential for unraveling its role in normal synaptic transmission and its potential as a therapeutic target for neurological disorders.

E.coli-derived human VGLUT2/SLC17A6 recombinant protein (Position: M1-K561) . Human SLC17A6 shares 98.4% and 98.6% amino acid (aa) sequence identity with mouse and rat SLC17A6, respectively.

1. Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H., Yamada, Y., Inoue, I., Kojima, I., Takeda, J. Molecular cloning of a novel brain-type Na (+) -dependent inorganic phosphate cotransporter. J. Neurochem. 74: 2622-2625, 2000. 2. Aihara, Y., Onda, H., Teraoka, M., Yokoyama, Y., Seino, Y., Kasuya, H., Hori, T., Tomura, H., Inoue, I., Kojima, I., Takeda, J. Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na (+) -dependent inorganic phosphate cotransporter to human chromosome 11p14.3. Cytogenet. Cell Genet. 92: 167-169, 2001. 3. Bai, L., Xu, H., Collins, J. F., Ghishan, F. K. Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. J. Biol. Chem. 276: 36764-36769, 2001.