Anti-GLRX3 Antibody Picoband®

Glutaredoxin-3 is a protein that in humans is encoded by the GLRX3 gene. This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.

E.coli-derived human GLRX3 recombinant protein (Position: K31-V307) . Human GLRX3 shares 94.6% and 94.9% amino acid (aa) sequence identity with mouse and rat GLRX3, respectively.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 4/22/2009. 2. Haunhorst, P., Hanschmann, E.-M., Brautigam, L., Stehling, O., Hoffmann, B., Muhlenhoff, U., Lill, R., Berndt, C., Lillig, C. H. Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Molec. Biol. Cell 24: 1895-1903, 2013. 3. Jeong, D., Kim, J. M., Cha, H., Oh, J. G., Park, J., Yun, S.-H., Ju, E.-S., Jeon, E.-S., Hajjar, R. J., Park, W. J. PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling. Circ. Res. 102: 711-719, 2008.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.