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Anti-TOM1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene. This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name

TOM1

Gene ID

10043

UniProt

O60784

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human TOM1 recombinant protein (Position: R84-K480) . Human TOM1 shares 87.4% amino acid (aa) sequence identity with mouse TOM1.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Burk, O., Worpenberg, S., Haenig, B., Klempnauer, K. H. tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells. EMBO J. 16: 1371-1380, 1997. 2. Katoh, Y., Imakagura, H., Futatsumori, M., Nakayama, K. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem. Biophys. Res. Commun. 341: 143-149, 2006. 3. Keskitalo, S., Haapaniemi, E. M., Glumoff, V., Liu, X., Lehtinen, V., Fogarty, C., Rajala, H., Chiang, S. C., Mustjoki, S., Kovanen, P., Lohi, J., Bryceson, Y. T., Seppanen, M., Kere, J., Heiskanen, K., Varjosalo, M. Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease. NPJ Genomic Med. 4: 14, 2019.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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