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Anti-SOS1 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.

Gene Name

SOS1

Gene ID

6654

UniProt

Q07889

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human SOS1 recombinant protein (Position: H177-A1288) . Human SOS1 shares 96.5% amino acid (aa) sequence identity with mouse SOS1.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Bowtell, D., Fu, P., Simon, M. A., Senior, P. Identification of murine homologues of the Drosophila Son of sevenless gene: potential activators of ras. Proc. Nat. Acad. Sci. 89: 6511-6515, 1992. 2. Chardin, P., Camonis, J. H., Gale, N. W., Van Aelst, L., Schlessinger, J., Wigler, M. H., Bar-Sagi, D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260: 1338-1343, 1993. 3. Ferrero, G. B., Baldassarre, G., Delmonaco, A. G., Biamino, E., Banaudi, E., Carta, C., Rossi, C., Silengo, M. C. Clinical and molecular characterization of 40 patients with Noonan syndrome. Europ. J. Med. Genet. 51: 566-572, 2008.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

152 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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