Anti-SLD5/GINS4 Antibody Picoband® Fluoro594 Conjugated

The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610) . The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]) . See GINS1 for additional information about the GINS complex.

E.coli-derived human SLD5/GINS4 recombinant protein (Position: M1-I223) . Human GINS4 shares 87.9% and 88.8% amino acid (aa) sequence identity with mouse and rat GINS4, respectively.

1. Kong, L., Ueno, M., Itoh, M., Yoshioka, K., Takakura, N. Identification and characterization of mouse PSF1-binding protein, SLD5. Biochem. Biophys. Res. Commun. 339: 1204-1207, 2006. 2. Takayama, Y., Kamimura, Y., Okawa, M., Muramatsu, S., Sugino, A., Araki, H. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev. 17: 1153-1165, 2003. 3. Ueno, M., Itoh, M., Kong, L., Sugihara, K., Asano, M., Takakura, N. PSF1 is essential for early embryogenesis in mice. Molec. Cell Biol. 25: 10528-10532, 2005.