Anti-ITM2C Antibody Picoband®

Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE) 1 and the microtubule-destabilizing protein SCG10 (STMN2) . It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

E.coli-derived human ITM2C recombinant protein (Position: E33-D226) . Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse and rat ITM2C.

1. Vidal, R., Calero, M., Revesz, T., Plant, G., Ghiso, J., Frangione, B. Sequence, genomic structure and tissue expression of human BRI (3), a member of the BRI gene family. Gene 266: 95-102, 2001. 2. Wickham, L., Benjannet, S., Marcinkiewicz, E., Chretien, M., Seidah, N. G. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI (3) : binding partners processed by furin. J. Neurochem. 92: 93-102, 2005.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.