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Anti-HTRA4 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.

Gene Name

HTRA4

Gene ID

203100

UniProt

P83105

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human HTRA4 recombinant protein (Position: A31-D464) . Human HTRA4 shares 68.7% and 68.9% amino acid (aa) sequence identity with mouse and rat HTRA4, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Clausen, T., Southan, C., Ehrmann, M. The HtrA family of proteases: implications for protein composition and cell fate. Molec. Cell 10: 443-455, 2002. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/12/2007.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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