Anti-ISOC2 Antibody Picoband® Fluoro647 Conjugated

ISOC2 (isochorismatase domain-containing protein 2) is a 205 amino acid protein belonging to the isochorismatase family. Isochorismatase is an enzyme that catalyzes the chemical reaction of isochorismate and water to 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate. Localized to mitochondrion and cytoplasm, ISOC2 interacts with CDKN2A and localizes to the nucleus in the presence of it. ISOC2 is ubiquitously expressed, with highest levels found in uterus, stomach and urinary tract system. Over-expressed ISOC2 inhibits the expression of CDKN2A, suggesting that this novel gene may play a role during tumor development by interacting with CDKN2A. Three isoforms are produced by alternative splicing events.

E.coli-derived human ISOC2 recombinant protein (Position: M1-H205) . Human ISOC2 shares 84.2% and 75% amino acid (aa) sequence identity with mouse and rat ISOC2, respectively.

1. Huang, X., Shi, Z., Wang, W., Bai, J., Chen, Z., Xu, J., Zhang, D., Fu, S. Identification and characterization of a novel protein ISOC2 that interacts with p16 (INK4a) . Biochem. Biophys. Res. Commun. 361: 287-293, 2007.