Anti-Islet 1/ISL1 Antibody Picoband® Fluoro488 Conjugated

Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the isl1 gene. This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

E.coli-derived human ISL1 recombinant protein (Position: D118-Q289) . Human Islet 1/ISL1 shares 100% amino acid (aa) sequence identity with both mouse and rat ISL1.

1. Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1) . 2. Gay F, Anglade I, Gong Z, Salbert G (October 2000) . The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol. Endocrinol. 14 (10) : 1627–48. 3. Tanizawa Y, Riggs AC, Dagogo-Jack S, Vaxillaire M, Froguel P, Liu L, Donis-Keller H, Permutt MA (July 1994) . Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]. Diabetes. 43 (7) : 935–41.