Anti-IRF2BP1 Antibody Picoband® Fluoro647 Conjugated

IRF2BP1 (Interferon regulatory factor 2 binding protein 1) is a 64-66 kDa member of the IFR2BP family of proteins. It is widely expressed, and known to bind to the C-terminus of IRF-2, creating a transcriptional repressor complex. IRF2BP1 also bind to JDP2 (Jun dimerization protein 2), promoting its ubiquitination. Human IRF2BP1 is 584 amino acids (aa) in length. It contains two Zn-finger domains (aa 6-67 and 498-584), one coiled-coil region (aa 197-217), a Cys-rich region (aa 503?550), an N-terminal acetylation site at Ala2, and multiple utilized phosphorylation sites at Ser 66/125/186/384/421/436/453/457. Over aa 188-356, human and mouse IRF2BP1 are identical in amino acid sequence.

E.coli-derived human IRF2BP1 recombinant protein (Position: A71-D439) . Human IRF2BP1 shares 95.1% amino acid (aa) sequence identity with mouse IRF2BP1.

1. Childs, K. S., Goodbourn, S. Identification of novel co-repressor molecules for interferon regulatory factor-2. Nucleic Acids Res. 31: 3016-3026, 2003. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/23/2013. 3. Kimura, M. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. FEBS Lett. 582: 2833-2837, 2008.