Anti-IQCE Antibody Picoband®

IQ domain-containing protein E is a protein that in humans is encoded by the IQCE gene. Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5?% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.

1. Estrada-Cuzcano, A., Etard, C., Delvallee, C., Stoetzel, C., Schaefer, E., Scheidecker, S., Geoffroy, V., Schneider, A., Studer, F, Mattioli, F., Chennen, K., Sigaudy, S., Plassard, D., Poch, O., Piton, A., Strahle, U., Muller, J., Dollfus, H. Novel IQCE variations confirm its role in postaxial polydactyly and cause ciliary defect phenotype in zebrafish. Hum. Mutat. 41: 240-254, 2020. 2. Kikuno, R., Nagase, T., Ishikawa, K., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 197-205, 1999. 3. Pusapati, G. V., Hughes, C. E., Dorn, K. V., Zhang, D., Sugianto, P., Aravind, L., Rohatgi, R. EFCAB7 and IQCE regulate Hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Dev. Cell 28: 483-496, 2014.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.