Anti-MYH14 Antibody Picoband® Fluoro647 Conjugated

Myosin-14 is a protein that in humans is encoded by the MYH14 gene. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14) . Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.

1. Choi, B.-O., Kang, S. H., Hyun, Y. S., Kanwal, S., Park, S. W., Koo, H., Kim, S.-B., Choi, Y.-C., Yoo, J. H., Kim, J.-W., Park, K. D., Choi, K.-G., Kim, S. J., Zuchner, S., Chung, K. W. A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14. Hum. Mutat. 32: 669-677, 2011. 2. Donaudy, F., Snoeckx, R., Pfister, M., Zenner, H.-P., Blin, N., Di Stazio, M., Ferrara, A., Lanzara, C., Ficarella, R., Declau, F., Pusch, C. M., Nurnberg, P., Melchionda, S., Zelante, L., Ballana, E., Estivill, X., Van Camp, G., Gasparini, P., Savoia, A. Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4) . Am. J. Hum. Genet. 74: 770-776, 2004. 3. Golomb, E., Ma, X., Jana, S. S., Preston, Y. A., Kawamoto, S., Shoham, N. G., Goldin, E., Conti, M. A., Sellers, J. R., Adelstein, R. S. Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family. J. Biol. Chem. 279: 2800-2808, 2004.