Anti-GART Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene. The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Gene Name

GART

Gene ID

2618

UniProt

P22102

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human GART recombinant protein (Position: E68-E1010) . Human GART shares 86.2% amino acid (aa) sequence identity with mouse GART.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Brodsky, G., Barnes, T., Bleskan, J., Becker, L., Cox, M., Patterson, D. The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome. Hum. Molec. Genet. 6: 2043-2050, 1997. 2. Chadefaux, B., Allard, D., Rethore, M. O., Raoul, O., Poissonnier, M., Gilgenkrantz, S., Cheruy, C., Jerome, H. Assignment of human phosphoribosylglycinamide synthetase locus to region 21q221. Hum. Genet. 66: 190-192, 1984. 3. Cox, D. R., Goldblatt, D., Epstein, C. J. Chromosomal assignment of mouse PRGS: further evidence for homology between mouse chromosome 16 and human chromosome 21. (Abstract) Am. J. Hum. Genet. 33: 145A only, 1981.