Anti-GALNT12 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.

Gene Name

GALNT12

Gene ID

79695

UniProt

Q8IXK2

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human GALNT12 recombinant protein (Position: E49-Q572) . Human GALNT12 shares 86.8% amino acid (aa) sequence identity with mouse GALNT12.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Guda, K., Moinova, H., He, J., Jamison, O., Ravi, L., Natale, L., Lutterbaugh, J., Lawrence, E., Lewis, S., Willson, J. K. V., Lowe, J. B., Wiesner, G. L., and 10 others. Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc. Nat. Acad. Sci. 106: 12921-12925, 2009. 2. Guo, J.-M., Zhang, Y., Cheng, L., Iwasaki, H., Wang, H., Kubota, T., Tachibana, K., Narimatsu, H. Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. FEBS Lett. 524: 211-218, 2002.