Anti-GALNT12 Antibody Picoband® Fluoro488 Conjugated

This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.

E.coli-derived human GALNT12 recombinant protein (Position: E49-Q572) . Human GALNT12 shares 86.8% amino acid (aa) sequence identity with mouse GALNT12.

1. Guda, K., Moinova, H., He, J., Jamison, O., Ravi, L., Natale, L., Lutterbaugh, J., Lawrence, E., Lewis, S., Willson, J. K. V., Lowe, J. B., Wiesner, G. L., and 10 others. Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc. Nat. Acad. Sci. 106: 12921-12925, 2009. 2. Guo, J.-M., Zhang, Y., Cheng, L., Iwasaki, H., Wang, H., Kubota, T., Tachibana, K., Narimatsu, H. Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. FEBS Lett. 524: 211-218, 2002.