Anti-IDH3B Antibody Picoband®

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial is an enzyme that in humans is encoded by the IDH3B gene. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD (+) -dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD (+) -dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

1. Hartong, D. T., Dange, M., McGee, T. L., Berson, E. L., Dryja, T. P., Colman, R. F. Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle. Nature Genet. 40: 1230-1234, 2008. 2. Kim, Y.-O., Park, S.-H., Kang, Y.-J., Koh, H.-J., Kim, S.-H., Park, S.-Y., Sohn, U., Huh, T.-L. Assignment of mitochondrial NAD (+) -specific isocitrate dehydrogenase beta subunit gene (IDH3B) to human chromosome band 20p13 by in situ hybridization and radiation hybrid mapping. Cytogenet. Cell Genet. 86: 240-241, 1999. 3. Zenteno, J. C., Garcia-Montano, L. A., Cruz-Aguilar, M., Ronquillo, J., Rodas-Serrano, A., Aguilar-Castul, L., Matsui, R., Vencedor-Meraz, C. I., Arce-Gonzalez, R., Graue-Wiechers, F., Gutierrez-Paz, M., Urrea-Victoria, T., de Dios Cuadras, U., Chacon-Camacho, O. F. Extensive genic and allelic heterogeneity underlying inherited retinal dystrophies in Mexican patients molecularly analyzed by next-generation sequencing. Molec. Genet. Genomic Med. 8: e1044, 2020. Note: Electronic Article.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.