Anti-NRTN Antibody Picoband® Fluoro647 Conjugated

Neurturin (NRTN) is a protein that is encoded in humans by the NRTN gene. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.

E.coli-derived human Neurturin/NRTN recombinant protein (Position: M1-V197) . Human Neurturin/NRTN shares 86.3% amino acid (aa) sequence identity with mouse Neurturin/NRTN.

1. Doray, B., Salomon, R., Amiel, J., Pelet, A., Touraine, R., Billaud, M., Attie, T., Bachy, B., Munnich, A., Lyonnet, S. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Hum. Molec. Genet. 7: 1449-1452, 1998. Note: Erratum: Hum. Molec. Genet. 7: 1831 only, 1998. 2. Heuckeroth, R. O., Kotzbauer, P., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Zimonjic, D. B., Popescu, N. C., Johnson, E. M., Jr., Milbrandt, J. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Genomics 44: 137-140, 1997. 3. Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson, E. M., Jr., Milbrandt, J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384: 467-470, 1996.