Anti-GATB Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
GATB allows the formation of correctly charged Gln-tRNA (Gln) through the transamidation of misacylated Glu-tRNA (Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA (Gln) .
Gene Name
GATB
Gene ID
5188
UniProt
O75879
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
E.coli-derived human GATB recombinant protein (Position: R113-E443) . Human GATB shares 89.7% amino acid (aa) sequence identity with mouse GATB.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Friederich, M. W., Timal, S., Powell, C. A., Dallabona, C., Kurolap, A., Palacios-Zambrano, S., Bratkovic, D., Derks, T. G. J., Bick, D., Bouman, K., Chatfield, K. C., Damouny-Naoum, N., and 41 others. Pathogenic variants in glutamyl-tRNA (Gln) amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nature Commun. 9: 4065, 2018. Note: Electronic Article. 2. Gross, M. B. Personal Communication. Baltimore, Md. 11/30/2016. 3. Nagao, A., Suzuki, T., Katoh, T., Sakaguchi, Y., Suzuki, T. Biogenesis of glutaminyl-mt tRNA (Gln) in human mitochondria. Proc. Nat. Acad. Sci. 106: 16209-16214, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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