Anti-MGARP Antibody Picoband® Fluoro488 Conjugated

MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2–4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155) . Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

1. Jia, L., Liang, T., Yu, X., Ma, C., Zhang, S. MGARP regulates mouse neocortical development via mitochondrial positioning. Molec. Neurobiol. 49: 1293-1308, 2014. 2. Matsumoto, T., Minegishi, K., Ishimoto, H., Tanaka, M., Hennebold, J. D., Teranishi, T., Hattori, Y., Furuya, M., Higuchi, T., Asai, S., Kim, S. H., Miyakoshi, K., Yoshimura, Y. Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis. Endocrinology 150: 3353-3359, 2009. 3. Qi, S., Wang, Y., Zhou, M., Ge, Y., Yan, Y., Wang, J., Zhang, S. S.-M., Zhang, S. A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder. Molec. Biol. Rep. 38: 2869-2877, 2011.