Anti-LRRC40 Antibody Picoband®

Leucine rich repeat containing 40 (LRRC40) is a protein that in humans is encoded by the LRRC40 gene. The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic α/β horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The primary function of these motifs is to provide a versatile structural framework to mediate the formation of protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. LRRC40 (leucine rich repeat containing 40) is a 602 amino acid protein that contains 20 LRR (leucine-rich) repeats.

1. Pijuan, J. , Juan Darío Ortigoza‐Escobar, Ortiz, J. , Adrián Alcalá, María José Calvo, & Cubells, M. , et al. (2021) . Plxna2 and lrrc40 as candidate genes in autism spectrum disorder. Autism Research. 2. Liu, H. , Cui, J. , Zhang, Y. , Niu, M. , Xue, X. , & Yin, H. , et al. (2019) . Mass spectrometry‐based proteomic analysis of fscn1‐interacting proteins in laryngeal squamous cell carcinoma cells. IUBMB Life, 71 (11) . 3. Wang, Y. , Du, S. , Zhu, C. , Wang, C. , & Cai, Q. . (2020) . Stub1 is targeted by the sumo-interacting motif of ebna1 to maintain epstein-barr virus latency. PLoS Pathogens, 16 (3), e1008447.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.