Anti-LRRC1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells. Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions. It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.
Gene Name
LRRC1
Gene ID
55227
UniProt
Q9BTT6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human LRRC1 recombinant protein (Position: L120-R497) . Human LRRC1 shares 91.8% amino acid (aa) sequence identity with mouse LRRC1.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Saito, H., Santoni, M.-J., Arsanto, J.-P., Jaulin-Bastard, F., Le Bivic, A., Marchetto, S., Audebert, S., Isnardon, D., Adelaide, J., Birnbaum, D., Borg, J.-P. Lano, a novel LAP protein ly connected to MAGUK proteins in epithelial cells. J. Biol. Chem. 276: 32051-32055, 2001.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
