Anti-LYRM4 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis.

Gene Name

LYRM4

Gene ID

57128

UniProt

Q9HD34

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human LYRM4 recombinant protein (Position: M1-T91) . Human LYRM4 shares 89% amino acid (aa) sequence identity with mouse LYRM4.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Adam, A. C., Bornhovd, C., Prokisch, H., Neupert, W., Hell, K. The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J. 25: 174-183, 2006. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 3/17/2010. 3. Lim, S. C., Friemel, M., Marum, J. E., Tucker, E. J., Bruno, D. L., Riley, L. G., Christodoulou, J., Kirk, E. P., Boneh, A., DeGennaro, C. M., Springer, M., Mootha, V. K., Rouault, T. A., Leimkuhler, S., Thorburn, D. R., Compton, A. G. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Hum. Molec. Genet. 22: 4460-4473, 2013.