Anti-LYRM4 Antibody Picoband®

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis.

1. Adam, A. C., Bornhovd, C., Prokisch, H., Neupert, W., Hell, K. The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J. 25: 174-183, 2006. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 3/17/2010. 3. Lim, S. C., Friemel, M., Marum, J. E., Tucker, E. J., Bruno, D. L., Riley, L. G., Christodoulou, J., Kirk, E. P., Boneh, A., DeGennaro, C. M., Springer, M., Mootha, V. K., Rouault, T. A., Leimkuhler, S., Thorburn, D. R., Compton, A. G. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Hum. Molec. Genet. 22: 4460-4473, 2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.