Anti-LYAR Antibody Picoband® Fluoro488 Conjugated

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone) . LYAR (Ly-1/CD5 antibody reactive clone) is a 45-50 kDa nucleolar protein that was named for the ability of its antibody to cross-react with Ly-1. Its function is unclear; it is known to associate with MYCN and RRP1B, the latter association giving rise to the suggestion that LYAR is involved with RNA metabolism. Human LYAR is 379 amino acids (aa) in length. It contains two C2H2-type Zn finger regions (aa 6-25 and 33-51) followed by one coiled-coil region (aa 175-219) and an NLS (aa 217-222) . There are multiple Zn-binding sites and three utilized phosphorylation sites at Ser244, Ser258 and Ser276. Over aa 288-379, human LYAR shares 75% aa identity with mouse LYAR.

E.coli-derived human LYAR recombinant protein (Position: M1-K379) . Human LYAR shares 71.9% and 73.7% amino acid (aa) sequence identity with mouse and rat LYAR, respectively.

1. Gross, M. B. Personal Communication. Baltimore, Md. 9/21/2017. 2. Ju, J., Wang, Y., Liu, R., Zhang, Y., Xu, Z., Wang, Y., Wu, Y., Liu, M., Cerruti, L., Zou, F., Ma, C., Fang, M., Tan, R., Jane, S. M., Zhao, Q. Human fetal globin gene expression is regulated by LYAR. Nucleic Acids Res. 42: 9740-9752, 2014. 3. Su, L., Hershberger, R. J., Weissman, I. L. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Genes Dev. 7: 735-748, 1993.