Anti-FOXM1 Antibody Picoband® Fluoro594 Conjugated

Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 brain washes normal cells to adopt cancer-like epigenome.

E.coli-derived human FOXM1 recombinant protein (Position: K48-Q763) . Human FOXM1 shares 78.9% and 81.1% amino acid (aa) sequence identity with mouse and rat FOXM1, respectively.

1. Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA, Costa RH (March 1997) . Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol Cell Biol 17 (3) : 1626–41. 2. Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H (March 1998) . The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics 46 (3) : 435–42. 3. Wierstra I, Alves J (December 2007) . FOXM1, a typical proliferation-associated transcription factor. Biol. Chem. 388 (12) : 1257–74.